It promises to be one of the major games in Europe even as the Italian Serie A begins this weekend.
Both managers would be out to outwit each other while the pressure would be on Arsenal manager Mikel Arteta to make the difference.
Arsenal's defeat to Brentford away last week leaves them with no other option but to win irrespective of the opposition they face in Chelsea.
As the two sides get set to take to the pitch, we evaluate three key players' battles that can define the London Derby at the Emirates Stadium.
Ben White vs. Romelu Lukaku
It will be a battle between these two new signings as both players hope to assert their influence in the match.
It promises to be a tough one for Ben owing to the physical nature of the player he’s going to face this weekend.
With the above been said Lukaku must get down to business as he will be left to also prove that he merits the whooping price, he was bought for.
Defender Ben White has the talent to compete at the highest level but it's left for him to prove his mettle against the rugged playing Lukaku in the Arsenal area.
Granit Xhaka vs. N'Golo Kante
Here, it’s going to be a battle of experience as the initially want-away midfielder Xhaka competes against his Chelsea counterpart in N’Golo Kante.
Xhaka’s ability on the ball will be put to the test by French mercurial midfielder Kante as both players square upon the pitch.
Kante would look to impose his presence in midfield while trying to clear every ball available within his reach like his former number Ramires used to do at Chelsea some years back.
But it remains to be seen if Kante's midfield correlation would be enough to stop Granit Xhaka from having a good game for Arsenal.
The Swiss star is expected to exhibit his trademark passing range to perfection when they file out against the tactics-driven Chelsea side.
Nicholas Pepe vs. Marcos Alonso
It’s a battle of left-sided players as Arsenal Pepe would confront Marcos Alonso who is seen to be rich in confidence following his superb free-kick goal against Crystal Palace.
Alonso is an outstanding outlet for Chelsea but could he be able to checkmate Pepe’s run in the byline?
While the Ivorians technicality will be needed to unsettle the Blues left-back in his defensive position.
But how resolute can the Spaniard be as he faces the trickery of the Arsenal man in this contest?
This article was most recently revised and updated 8 months ago