Arsenal know that victory at the Emirates over Ole Gunnar Solskaer's in-form side will not only see them move above the Old Trafford and back into the top four, it will also see them move to within just one point of Tottenham in third.
So it's all to play for in north London, with Unai Emery's side aiming to bounce back from Thursday night's disappointing 3-1 defeat against Rennes in the Europa League.
The hosts will be without key midfielder Lucas Torreira for the game due to suspension, with the Uruguay international having been sent off in the closing stages of last weekend's 1-1 draw in the north London derby.
Alexandre Lacazette will be available again, having sat out Thursday's game in the Europa League due to his own ban, and is expected to come straight back into the side, with the out of form Pierre-Emerick Aubameyang likely to drop to the bench.
Aaron Ramsey, who was on the bench in Rennes, is also expected to come back into the starting XI – with Emery set to go with the same front line that started against Spurs last week, meaning Mesut Ozil will miss out.
Matteo Guendouzi and Granit Xhaka will make up the midfield partnership, with Sead Kolasinac possibly the only change from the back four that started at Wembley last weekend.
Arsenal XI vs Manchester United (3-4-2-1)
Leno, Mustafi, Sokratis, Koscielny, Kolasinac, Guendouzi, Xhaka, Iwobi, Ozil, Mkhitaryan, Lacazette.
This article was most recently revised and updated 3 years ago