Watford under-23 coach Hayden Mullins will take charge of Wednesday’s Premier League game at Leicester following the sacking of Quique Sanchez Flores.
Flores returned for a second spell at the club when he replaced Javi Gracia in September but was fired after Saturday’s defeat by Southampton.
Sanchez Flores won just one of his 10 league games since returning to Vicarage Road in September.
The Hornets are bottom of the Premier League table, six points from safety.
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Chris Hughton is a possible successor and Watford said a replacement will be appointed “imminently”.