The Red Devils could be boosted by Marcus Rashford’s comeback from an ankle injury as he'll feature in Manchester United line-up vs Southampton.
The England striker suffered an ankle injury against Liverpool last weekend and was forced to start on the bench against Crystal Palace but is now available to face Saints.
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Anthony Martial remains a doubt after a groin problem and is not likely to be risked with a Champions League clash against Paris Saint-Germain on the way.
Antonio Valencia and Matteo Darmian are both on the treatment table while Phil Jones is still a doubt and Marcos Rojo is short of match action.
With Rashford starting, Romelu Lukaku is expected to shift out to the right flank after his two goals against Palace while Alexis Sanchez could start once more on the opposite wing.
Paul Pogba is expected to be joined by Scott McTominay and Fred in central midfield, although Andreas Pereira provides another option.
Luke Shaw and Victor Lindelof will be joined by either Chris Smalling or Eric Bailly in defence while Diogo Dalot may possibly deputise for Ashley Young if the veteran full-back is rested.
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Manchester United line-up vs Southampton
Manchester United (4-3-3):
Pre Match INSIGHTS
- Manchester United have won just one of their five home Premier League games against Southampton since Sir Alex Ferguson retired (W1 D2 L2) – under Ferguson, they won 13 out of 14 against the Saints at Old Trafford (D1).
- Southampton have drawn their last two league matches against Man Utd; they haven’t avoided defeat in three consecutively against them since May 1989 (five games).
- Since the 2013-14 campaign, only Manchester City and West Bromwich Albion (3) have won more away Premier League games at Old Trafford than Southampton (2).
- In Premier League history, Manchester United have come from behind to win eight matches against Southampton, a joint-record in the competition with Manchester United also coming from behind eight times to win against Newcastle and Chelsea doing so against Sunderland.
- Southampton have won just one of their last 33 Premier League games against ‘big six’ opponents (D9 L23), beating Arsenal 3-2 in December.
This article was most recently revised and updated 4 years ago