Alexis Sanchez, Matteo Darmian and Antonio Valencia will all be missing for the Premier League fixture between Manchester United and Watford this weekend.
The new United boss will face a tricky test in his first official game in charge as he looks to return to winning ways following successive defeats against both Arsenal and Burnley.
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He will have to do so without a trio of first-team players.
“We've had a very good training week,” Solskjaer told the Official App.
“Alexis has just come back and there is only him who is out, along with Matteo and Antonio. Those three are out.”
“We'll have to check on one or two of the others.”
It remains to be seen which other first-team stars will feature in the match after a number of players had to withdraw from international duty over the past fortnight.
Romelu Lukaku remains a major doubt for the game while Anthony Martial and Marcus Rashford were also forced to withdraw from their respective international camps.
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Jesse Lingard is expected to undergo fitness tests ahead of the match, while Eric Bailly missed Ivory Coast's second international fixture having suffered a head collision in their earlier win vs Rwanda.
This article was most recently revised and updated 4 years ago