Two goals from Edinson Cavani sank Portugal and Cristiano Ronaldo's hopes of World Cup success as they lost 2-1 in Sochi.
Cavani scored once in each half as the Uruguayans prevailed in the second round game to set up a quarter-final date with France on Friday at the Nizhny Novgorod Stadium.
The Paris Saint-Germain forward had leaped beautifully to get on the end of Luis Suarez's cross in the seventh minute to give Uruguay the lead.
Portugal struggled for a response but did level 10 minutes into the second half as Pepe scored from a header.
But Cavani scored from the edge of the area in the 62nd minute for what proved to the decisive goal of the match.
It is not all good news for Cavani, however, as he limped off injured before the end and he might not be available for the France match.
But for Portugal and Ronaldo the 2018 World Cup is over and they will depart Russia on Sunday to return home.
This article was most recently revised and updated 3 years ago