Manager Ole Gunnar Solskjaer has suggested that Raphael Varane would travel with the United squad to Southampton for Sunday's Premier League match.
The French defender is expected to make a fresh start to his career on the United red shirt. But he may end up starting among the substitutes since Victor Lindelof is expected to retain his place alongside Harry Maguire in the heart of United's defence.
Manchester United will be without the trio of Marcus Rashford, Alex Telles and Dean Henderson.
While defender Phil Jones is not expected to play a part in this match despite playing in a behind closed test game against Burnley early in the week.
Jesse Lingard is expected to contend for a start, though he's recovered from Coronavirus.
But striker Edinson Cavani is back at the club and could be placed on the substitute bench.
Jadon Sancho could make his first start for United since he featured off the bench against Leeds United.
There is a strong chance that could replace Daniel James in the starting team.
Manchester United boss Ole Gunnar Solskjaer may decide to go with the same side that started against Leeds United last week, with Paul Pogba who was impressive with four assists, operating off the left.
Fred and Scott Mc Tominay should keep their spot in the midfield pivot while Bruno Fernandes and Mason Greenwood should retain their place also in the starting team at St. Mary Stadium, this weekend.
Manchester United possible starting lineup:
David De Gea; Aaron Wan-Bissaka, Victor Lindelof, Harry Maguire, Luke Shaw; Fred, Scott Mc Tominay; Jadon Sancho, Bruno Fernandes, Paul Pogba; Mason Greenwood.
This article was most recently revised and updated 2 years ago