Alex Iwobi, Wilfred Ndidi and Kelechi Iheanacho are among the stars set to miss upcoming World Cup Qualifiers unless quarantine rules are lifted.
According to Sky Sports, European Club Association (ECA) members are set to prevent their players from going to ‘red-list' countries during September's international.
The Premier League is currently in talks with the Department for Digital, Culture, Media, and Sport (DCMS).
Argentina, Chile, Colombia, Mexico, Turkey, Uruguay, Brazil and Egypt are among the nations currently on the UK Government's “red” list regarding travel to England, meaning a 10-day period of hotel isolation would be required before players can return to their clubs.
That would mean, Oghenekaro Etebo, William Troost Ekong and Mohamed Salah will not be able to play their countries World Cup Qualifier next month.
Unless quarantine issues can be resolved, a host of other Premier League players may be unavailable for international matches next month, so too PSG stars Lionel Messi and Neymar, as well as Marquinhos and Angel Di Maria.
Aston Villa and Argentina goalkeeper Emiliano Martinez would likewise be prevented from playing his nation's qualifiers.
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It is not yet known whether Barcelona, Juventus and Real Madrid, who did not retain their ECA membership following the European Super League fallout, will allow their players to travel.
This article was most recently revised and updated 2 years ago